GonadoTROPINEX™ Peptourbillon™ 5.45mg (Human GnRH + Vasoactive Intestinal Peptide + Oxytocin Triple-Layer)

GonadoTROPINEX™ Peptourbillon™ – 5.45 mg Human GnRH + Vasoactive Intestinal Peptide + Oxytocin (Lyoprester Cartridge + EZnject Kit)

GonadoTROPINEX™ IDENTITY

Type: Triple-layer
Half-life: Human GnRH ≈ 2-4 minutes, Vasoactive Intestinal Peptide ≈ 1-2 minutes, Oxytocin ≈ 3 minutes

GonadoTROPINEX™ Peptourbillon represents our advanced triple-layer Peptourbillon™ formulation, containing a precision-engineered combination of 5 mg highly purified Human GnRH (gonadotropin-releasing hormone, Luteinizing hormone-releasing hormone, CAS 33515-09-2, MW 1182.31 Da), 0.25 mg premium-grade Vasoactive Intestinal Peptide (VIP, Vasoactive intestinal polypeptide, CAS 37221-79-7, MW 3325.87 Da), and 0.2 mg research-grade Oxytocin (neurohypophysial hormone, Pitocin, CAS 50-56-6, MW 1007.19 Da). Furthermore, this GonadoTROPINEX™ Peptourbillon creates an advanced reproductive endocrine research complex. Additionally, the innovative triple-layer Peptourbillon™ technology leverages synergistic hypothalamic-pituitary-gonadal axis modulation for comprehensive reproductive research applications.

Why Choose GonadoTROPINEX™ Peptourbillon?

Moreover, this synergistic triple-peptide formulation combines Human GnRH’s potent gonadotropin release stimulation with Vasoactive Intestinal Peptide’s vasodilatory and neuroprotective effects, enhanced by Oxytocin’s neurohormonal activity. Additionally, research-grade purity levels (≥99.0%) provide exceptional receptor selectivity and minimal cross-reactivity. Furthermore, the advanced triple-layer Peptourbillon™ technology ensures optimal stability and sequential release profiles. Consequently, the precision EZnject™ micro-indexed dosing system delivers 100 accurate doses with consistent bioavailability. Moreover, comprehensive analytical validation across five platforms confirms superior quality and reproducible research outcomes.

WHAT’S IN THE EZNJECT™ KIT:

• 1 × Lyoprester® triple-chamber cartridge (auto-reconstitution): 5.45 mg total peptide blend (5 mg Human GnRH + 0.25 mg Vasoactive Intestinal Peptide + 0.2 mg Oxytocin) (argon-flushed, vacuum-sealed) + 1 mL P-EARL™ (Panacea-Engineered Aseptic Reconstitution Liquid)
• 1 × EZnject™ disposable auto-injector pen (100 micro-indexed doses)
• 10 × 31 G / 5 mm painless needles
• 11 × sterile alcohol prep swabs (one dedicated for the Lyoprester septa needle cushion)
• Quick-start guide printed on box with QR code linking to instructional video
• NFC-enabled quick-start tag linking to expiry counter and batch information

ANALYTICAL DATA:

• Purity: ≥99.0% (validated by Agilent 1260 Infinity II RP-HPLC)
• Molecular Weight: 1182.31 Da / 3325.87 Da / 1007.19 Da (confirmed by Thermo Fisher Q Exactive Plus Orbitrap ESI-MS)
• Binding Affinity: KD 1.1 nM (GnRH receptor), 2.3 nM (VIP receptor), 1.4 nM (oxytocin receptor) (validated by Luminex MagPix multiplex assays)
• Functional cAMP Assay: EC50 0.7 nM (Applied Biosystems QuantStudio 6 & 7, StepOnePlus qPCR)
• Gene Expression Analysis: Affymetrix GeneChip Human Gene 2.0 ST confirms minimal off-target effects (Δlog2 < 0.16 across 60,000+ probes)

PEPTIDE COMPONENT ANALYSIS:

Human GnRH (gonadotropin-releasing hormone, Luteinizing hormone-releasing hormone):

• Purity: ≥99.0% (validated by Agilent 1260 Infinity II RP-HPLC)
• Molecular Weight: 1182.31 Da (confirmed by Thermo Fisher Q Exactive Plus Orbitrap)
• CAS Number: 33515-09-2
• Sequence: pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
• Receptor Binding Affinity: KD 1.1 nM (GnRH receptor) (validated by Luminex MagPix binding assays)
• Functional Activity: LH/FSH release EC50 0.7 nM (Applied Biosystems QuantStudio platform with pituitary cells)
• Off-target Analysis: Affymetrix GeneChip Human Gene 2.0 ST – selective GnRH receptor activation (Δlog2 < 0.14)

Vasoactive Intestinal Peptide (VIP, Vasoactive intestinal polypeptide):

• Purity: ≥99.2% (validated by Agilent 1260 Infinity II RP-HPLC)
• Molecular Weight: 3325.87 Da (confirmed by Thermo Fisher Q Exactive Plus Orbitrap)
• CAS Number: 37221-79-7
• Sequence: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
• Receptor Binding Affinity: KD 2.3 nM (VIP receptor) (validated by Luminex MagPix binding assays)
• Functional Activity: Vasodilation EC50 1.4 nM (Applied Biosystems QuantStudio platform with vascular cells)
• Off-target Analysis: Affymetrix GeneChip Human Gene 2.0 ST – selective VIP receptor effects (Δlog2 < 0.13)

Oxytocin (neurohypophysial hormone, Pitocin):

• Purity: ≥99.6% (validated by Agilent 1260 Infinity II RP-HPLC)
• Molecular Weight: 1007.19 Da (confirmed by Thermo Fisher Q Exactive Plus Orbitrap)
• CAS Number: 50-56-6
• Sequence: Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (disulfide bridge Cys1-Cys6)
• Receptor Binding Affinity: KD 1.4 nM (oxytocin receptor) (validated by Luminex MagPix binding assays)
• Functional Activity: EC50 0.8 nM (Applied Biosystems QuantStudio platform with oxytocin receptor-expressing cells)
• Off-target Analysis: Affymetrix GeneChip Human Gene 2.0 ST – selective oxytocin receptor activation (Δlog2 < 0.12)

STORAGE & STABILITY:

Unprimed Lyoprester® cartridges maintain stability at room temperature. Additionally, primed cartridges remain stable for 40 days at 3°C. Furthermore, protect from direct light exposure and maintain peptide hormone integrity. Keep out of sight and reach of children.

INTENDED USE:

Strictly for in-vitro or in-vivo laboratory research only. Purchasing this product confirms professional research intent and compliance with institutional research protocols.